THCV (Tetrahydrocannabivarin)

A cannabinoid found in certain cannabis strains; it’s structurally similar to THC but with a few differences in effect.

Often referred to as the “diet weed” cannabinoid​​, THCV may block some of the CB1 receptors that THC activates (acting as a neutral antagonist or partial agonist), which can reduce hunger and possibly dampen THC’s psychoactivity​​. (Basically, the anti-munchies molecule—though branding experts are elbows-deep in focus group testing to see if “Weed Zero” is the catchier name).

Therapeutically, THCV is being eyed for obesity and anxiety (since it might provide energy and clear-headedness without paranoia)—but it’s very important to note that the science on THCV’s efficacy is just getting underway. What human studies do exist are small and not statistically significant.

Some current research on potential THCV benefits includes:

  • Moderating metabolic syndrome or diabetes due to its effect on insulin sensitivity and blood sugar (a human study showed improved glycemic control with THCV)​​
  • Possible stimulant and focus-enhancing properties (hence another nickname— “weederall”)

In higher doses, THCV can produce psychoactive effects of its own. People commonly report the high is clearer and shorter-lasting than a THC high. (If THC is the life of the party, THCV is the one tidying up the snack table. Thanks THCV!)

THCV is typically found in landrace sativas from Africa (like Durban Poison) and some Asian strains, though usually in small percentages. Modern breeding has created some strains and concentrates rich in THCV (e.g., Doug’s Varin, or isolated THCV vape cartridges).

Legally, THCV is not listed separately from THC in many places, and because it usually occurs in low amounts, it hasn’t been a focus of regulation. However, and perhaps without any real reason other than the letters "THC" appearing in its name, we are seeing some jurisdictions treat THCV as an illegal cannabinoid.

To sum up, THCV is a unique cannabinoid marketed, maybe without really good evidence to suppress appetite and potentially aid metabolic and cognitive function, earning it a reputation as a “lighter” or even diet-friendly version of cannabis’s effects​​.

The molecular structure of THCV overlaid on a photo of Cannabis foliage

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